According to reports, the accident occurred at about 1:20 pm on Tuesday.
An ambulance was said to have been travelling in a westerly direction when, upon reaching the traffic lights at Bon Air, Arouca, it came into contact with a black Honda Civic motor vehicle which was proceeding in a southerly direction.
At the time of impact, the ambulance was transporting an ill person to the Arima District Hospital.
The police and emergency health services were notified and the occupants of both vehicles were rushed to the hospital for treatment.
Investigations are ongoing to determine who was in the wrong.
More on this as it becomes available.
In a separate incident a woman was rescued after a car overturned in Tobago.