Reports say management of the establishment noticed the suspect on CCTV cameras inside the building around 5am and the alarm also tripped.
The police were notified immediately.
Upon arrival, officers cordoned off the area and ventured into the building to search for the man, who was believed to be armed.
They say he eluded capture by climbing into the ventilation ducts of the nightclub.
Traffic along Cipriani Boulevard was confined to one lane and vehicular access restricted along lower Woodford Street for about an hour.