"I feel great. I'm fully fit and can be chosen to play," Pepe said at a news conference on Saturday at the Stade de France.
The tough Real Madrid defender sat out a 2-0 win in the semifinals against Wales because of a thigh muscle injury.
The decision paid off for coach Fernando Santos not to risk his defensive leader against a Welsh attack that lacked the options France possesses.
Griezmann is the clearest danger to Portugal, with his six-goal tally at Euro 2016 double that of any player, including Cristiano Ronaldo, who has three.